George S Deepe Selected Research

Histoplasmosis

1/2021	A metabolic inhibitor arms macrophages to kill intracellular fungal pathogens by manipulating zinc homeostasis.
1/2018	Vaccination with an alkaline extract of Histoplasma capsulatum packaged in glucan particles confers protective immunity in mice.
11/2016	HcZrt2, a zinc responsive gene, is indispensable for the survival of Histoplasma capsulatum in vivo.
1/2015	Histoplasma capsulatum, lung infection and immunity.
4/2012	The role of cytokines and chemokines in Histoplasma capsulatum infection.
3/2012	CCR5 deficiency mitigates the deleterious effects of tumor necrosis factor α antagonism in murine histoplasmosis.
1/2012	Deciphering the pathways of death of Histoplasma capsulatum-infected macrophages: implications for the immunopathogenesis of early infection.
5/2010	Antigen-presenting dendritic cells rescue CD4-depleted CCR2-/- mice from lethal Histoplasma capsulatum infection.
12/2008	Histoplasma capsulatum proteome response to decreased iron availability.
1/2008	TNF-alpha antagonism generates a population of antigen-specific CD4+CD25+ T cells that inhibit protective immunity in murine histoplasmosis.

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George S Deepe Research Topics

Disease

32	Infections 11/2022 - 09/2002
17	Histoplasmosis 01/2021 - 07/2003
6	Mycoses (Diseases, Fungus) 12/2018 - 12/2004
4	Inflammation (Inflammations) 10/2020 - 05/2007
3	Hypoxia (Hypoxemia) 01/2020 - 01/2016
3	Paracoccidioidomycosis (South American Blastomycosis) 09/2008 - 03/2002
2	Virus Diseases (Viral Diseases) 01/2021 - 03/2004
2	Eosinophilia 10/2020 - 12/2018
2	Coinfection 12/2018 - 01/2006
2	Fungal Lung Diseases 01/2018 - 03/2004
1	Starvation 01/2021
1	Persistent Infection 01/2021
1	Asthma (Bronchial Asthma) 10/2020
1	Polyploidy 10/2020
1	Respiratory Hypersensitivity 10/2020
1	Atherosclerosis 01/2020
1	Non-alcoholic Fatty Liver Disease 01/2019
1	Disease Progression 01/2019
1	Heavy Metal Poisoning 10/2017
1	Hypertension (High Blood Pressure) 11/2016
1	Latent Tuberculosis 11/2016
1	Common Cold 09/2016
1	Anosmia 09/2016
1	Coccidioidomycosis 01/2013
1	Aspergillosis 05/2012
1	Autoimmune Diseases (Autoimmune Disease) 05/2007
1	Tuberculosis (Tuberculoses) 05/2007
1	Opportunistic Infections (Opportunistic Infection) 08/2005
1	Invasive Fungal Infections 06/2003

Drug/Important Bio-Agent (IBA)

9	CytokinesIBA 12/2021 - 09/2002
9	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2018 - 11/2003
7	VaccinesIBA 01/2018 - 06/2003
6	Proteins (Proteins, Gene)FDA Link 01/2019 - 09/2002
6	AntigensIBA 04/2015 - 08/2003
5	Interleukin-10 (Interleukin 10)IBA 12/2021 - 11/2003
5	ZincIBA 01/2021 - 09/2016
5	Interleukin-4 (Interleukin 4)IBA 12/2018 - 07/2003
2	LigandsIBA 11/2022 - 01/2016
2	Interferon-gamma (Interferon, gamma)IBA 01/2021 - 11/2016
2	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 10/2020 - 11/2003
2	AllergensIBA 10/2020 - 12/2018
2	Transcription Factors (Transcription Factor)IBA 01/2020 - 01/2016
2	Interleukin-5 (Interleukin 5)IBA 12/2018 - 01/2007
2	Oxygen (Dioxygen)IBA 03/2017 - 01/2016
1	Notch ReceptorsIBA 11/2022
1	N2- ((2S)- 2- (3,5- difluorophenyl)- 2- hydroxyethanoyl)- N1- ((7S)- 5- methyl- 6- oxo- 6,7- dihydro- 5H- dibenzo(b,d)azepin- 7- yl)- L- alaninamideIBA 11/2022
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 11/2022
1	Tricarboxylic AcidsIBA 12/2021
1	FumaratesIBA 12/2021
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2021
1	LactamsIBA 01/2021
1	Protein Tyrosine PhosphatasesIBA 01/2021
1	IronIBA 11/2020
1	Interferon Type IIBA 11/2020
1	Interleukin-33IBA 10/2020
1	LDL Receptors (LDL Receptor)IBA 01/2020
1	Interleukin-13IBA 12/2018
1	PapainIBA 12/2018
1	Melanins (Melanin)IBA 01/2018
1	CopperIBA 10/2017
1	MetallothioneinIBA 10/2017
1	Superoxides (Superoxide)IBA 10/2017
1	Carrier Proteins (Binding Protein)IBA 12/2016
1	LipidsIBA 11/2016
1	gluconic acid (gluconate)FDA LinkGeneric 09/2016
1	CalnexinIBA 04/2015
1	Fungal VaccinesIBA 04/2015
1	Immunosuppressive Agents (Immunosuppressants)IBA 01/2015
1	NADPH Oxidases (NAD(P)H oxidase)IBA 05/2012
1	ChemokinesIBA 04/2012
1	CaspasesIBA 01/2012
1	Chemokine ReceptorsIBA 08/2009
1	Interleukin-17 (Interleukin 17)IBA 07/2009
1	LeukotrienesIBA 12/2008
1	Chaperonin 60IBA 09/2008
1	Nitric Oxide Synthase (NO Synthase)IBA 06/2007
1	Tumor Necrosis Factor InhibitorsIBA 05/2007
1	Interleukin-1 (Interleukin 1)IBA 09/2006
1	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 09/2006
1	TEMPOIBA 08/2006
1	Monoclonal AntibodiesIBA 01/2006
1	Caspase InhibitorsIBA 10/2005
1	Recombinant ProteinsIBA 01/2005
1	EpitopesIBA 03/2004
1	Ki antigenIBA 03/2004
1	Membrane Proteins (Integral Membrane Proteins)IBA 10/2003
1	Fungal AntibodiesIBA 08/2003
1	Proteasome Endopeptidase Complex (Proteasome)IBA 09/2002
1	AntibodiesIBA 03/2002

Therapy/Procedure

3	Therapeutics 01/2021 - 01/2007